Genome-wide CRISPR/Cas9 screen shows that loss of GET4 increases mitochondria-endoplasmic reticulum...
Genome-wide CRISPR/Cas9 screen shows that loss of GET4 increases mitochondria-endoplasmic reticulum contact sites and is neuroprotective
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Author / Creator
Wilson, Emma L. , Yu, Yizhou , Leal, Nuno S. , Woodward, James A. , Patikas, Nikolaos , Morris, Jordan L. , Field, Sarah F. , Plumbly, William , Paupe, Vincent , Chowdhury, Suvagata R. , Antrobus, Robin , Lindop, Georgina E. , Adia, Yusuf M. , Loh, Samantha H. Y. , Prudent, Julien , Martins, L. Miguel and Metzakopian, Emmanouil
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Organelles form membrane contact sites between each other, allowing for the transfer of molecules and signals. Mitochondria-endoplasmic reticulum (ER) contact sites (MERCS) are cellular subdomains characterized by close apposition of mitochondria and ER membranes. They have been implicated in many diseases, including neurodegenerative, metabolic, a...
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Genome-wide CRISPR/Cas9 screen shows that loss of GET4 increases mitochondria-endoplasmic reticulum contact sites and is neuroprotective
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TN_cdi_doaj_primary_oai_doaj_org_article_2914aeb333b24972878c1604812247ee
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_2914aeb333b24972878c1604812247ee
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ISSN
2041-4889
E-ISSN
2041-4889
DOI
10.1038/s41419-024-06568-y
