Disruption of β-catenin-mediated negative feedback reinforces cAMP-induced neuronal differentiation...
Disruption of β-catenin-mediated negative feedback reinforces cAMP-induced neuronal differentiation in glioma stem cells
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Author / Creator
Chen, Zhijie , Zhong, Yingqian , Chen, Jiehong , Sun, Shuxin , Liu, Wenfeng , Han, Yu , Liu, Xincheng , Guo, Cui , Li, Depei , Hu, Wanming , Zhang, Peiyu , Chen, Zhuopeng , Chen, Zhongping , Mou, Yonggao , Yan, Guangmei , Zhu, Wenbo , Yin, Wei and Sai, Ke
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Accumulating evidence supports the existence of glioma stem cells (GSCs) and their critical role in the resistance to conventional treatments for glioblastoma multiforme (GBM). Differentiation therapy represents a promising alternative strategy against GBM by forcing GSCs to exit the cell cycle and reach terminal differentiation. In this study, we...
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Full title
Disruption of β-catenin-mediated negative feedback reinforces cAMP-induced neuronal differentiation in glioma stem cells
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TN_cdi_doaj_primary_oai_doaj_org_article_291e123fdb414f51bac2c92ab67ce0eb
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_291e123fdb414f51bac2c92ab67ce0eb
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ISSN
2041-4889
E-ISSN
2041-4889
DOI
10.1038/s41419-022-04957-9
