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ATM inhibitor KU60019 synergistically sensitizes lung cancer cells to topoisomerase II poisons by mu...

ATM inhibitor KU60019 synergistically sensitizes lung cancer cells to topoisomerase II poisons by mu...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_292868a365b34e8bbfbcb229d00b7730

ATM inhibitor KU60019 synergistically sensitizes lung cancer cells to topoisomerase II poisons by multiple mechanisms

About this item

Full title

ATM inhibitor KU60019 synergistically sensitizes lung cancer cells to topoisomerase II poisons by multiple mechanisms

Publisher

London: Nature Publishing Group UK

Journal title

Scientific reports, 2023-01, Vol.13 (1), p.882-12, Article 882

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

Type II topoisomerases (TOP2) poisons represent one class of the most successful and widely prescribed chemotherapeutics, which is frontline therapy for a myriad of systemic cancers and solid tumors, including lymphomas, leukemias, and lung cancer. Despite this, treatment with this class of drugs induces unwanted side effects (including cardiovascu...

Alternative Titles

Full title

ATM inhibitor KU60019 synergistically sensitizes lung cancer cells to topoisomerase II poisons by multiple mechanisms

Authors, Artists and Contributors

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_292868a365b34e8bbfbcb229d00b7730

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_292868a365b34e8bbfbcb229d00b7730

Other Identifiers

ISSN

2045-2322

E-ISSN

2045-2322

DOI

10.1038/s41598-023-28185-z

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