An iPSC-derived astrocyte model of fragile X syndrome exhibits dysregulated cholesterol homeostasis
An iPSC-derived astrocyte model of fragile X syndrome exhibits dysregulated cholesterol homeostasis
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Cholesterol is an essential membrane structural component and steroid hormone precursor, and is involved in numerous signaling processes. Astrocytes regulate brain cholesterol homeostasis and they supply cholesterol to the needs of neurons. ATP-binding cassette transporter A1 (ABCA1) is the main cholesterol efflux transporter in astrocytes. Here we...
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An iPSC-derived astrocyte model of fragile X syndrome exhibits dysregulated cholesterol homeostasis
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TN_cdi_doaj_primary_oai_doaj_org_article_2966caa23c6f430e8da00c2f5e4dd530
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_2966caa23c6f430e8da00c2f5e4dd530
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ISSN
2399-3642
E-ISSN
2399-3642
DOI
10.1038/s42003-023-05147-9
