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Activation of hTREK-1 by polyunsaturated fatty acids involves direct interaction

Activation of hTREK-1 by polyunsaturated fatty acids involves direct interaction

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_2993cabcc9044841a5df6184bb101207

Activation of hTREK-1 by polyunsaturated fatty acids involves direct interaction

About this item

Full title

Activation of hTREK-1 by polyunsaturated fatty acids involves direct interaction

Publisher

London: Nature Publishing Group UK

Journal title

Scientific reports, 2024-07, Vol.14 (1), p.15244-16, Article 15244

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

TREK-1 is a mechanosensitive channel activated by polyunsaturated fatty acids (PUFAs). Its activation is supposed to be linked to changes in membrane tension following PUFAs insertion. Here, we compared the effect of 11 fatty acids and ML402 on TREK-1 channel activation using the whole cell and the inside-out configurations of the patch-clamp techn...

Alternative Titles

Full title

Activation of hTREK-1 by polyunsaturated fatty acids involves direct interaction

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_2993cabcc9044841a5df6184bb101207

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_2993cabcc9044841a5df6184bb101207

Other Identifiers

ISSN

2045-2322

E-ISSN

2045-2322

DOI

10.1038/s41598-024-66192-w

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