Tau association with synaptic vesicles causes presynaptic dysfunction
Tau association with synaptic vesicles causes presynaptic dysfunction
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Author / Creator
Zhou, Lujia , McInnes, Joseph , Wierda, Keimpe , Holt, Matthew , Herrmann, Abigail G. , Jackson, Rosemary J. , Wang, Yu-Chun , Swerts, Jef , Beyens, Jelle , Miskiewicz, Katarzyna , Vilain, Sven , Dewachter, Ilse , Moechars, Diederik , De Strooper, Bart , Spires-Jones, Tara L. , De Wit, Joris and Verstreken, Patrik
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Tau is implicated in more than 20 neurodegenerative diseases, including Alzheimer’s disease. Under pathological conditions, Tau dissociates from axonal microtubules and missorts to pre- and postsynaptic terminals. Patients suffer from early synaptic dysfunction prior to Tau aggregate formation, but the underlying mechanism is unclear. Here we show...
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Full title
Tau association with synaptic vesicles causes presynaptic dysfunction
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TN_cdi_doaj_primary_oai_doaj_org_article_29d0e0f57e0642e99099f85ef88b2518
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_29d0e0f57e0642e99099f85ef88b2518
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms15295
