Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following tra...
Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Older organs represent an untapped potential to close the gap between demand and supply in organ transplantation but are associated with age-specific responses to injury and increased immunogenicity, thereby aggravating transplant outcomes. Here we show that cell-free mitochondrial DNA (cf-mt-DNA) released by senescent cells accumulates with aging...
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Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation
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TN_cdi_doaj_primary_oai_doaj_org_article_2a2a4da6a7984ebfa0d0c386e1408c60
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_2a2a4da6a7984ebfa0d0c386e1408c60
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-18039-x
