Retromer stabilization results in neuroprotection in a model of Amyotrophic Lateral Sclerosis
Retromer stabilization results in neuroprotection in a model of Amyotrophic Lateral Sclerosis
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Author / Creator
Muzio, Luca , Sirtori, Riccardo , Gornati, Davide , Eleuteri, Simona , Fossaghi, Andrea , Brancaccio, Diego , Manzoni, Leonardo , Ottoboni, Linda , Feo, Luca De , Quattrini, Angelo , Mastrangelo, Eloise , Sorrentino, Luca , Scalone, Emanuele , Comi, Giancarlo , Marinelli, Luciana , Riva, Nilo , Milani, Mario , Seneci, Pierfausto and Martino, Gianvito
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Amyotrophic Lateral Sclerosis (ALS) is a fatal disease characterized by the degeneration of upper and lower motor neurons (MNs). We find a significant reduction of the retromer complex subunit VPS35 in iPSCs-derived MNs from ALS patients, in MNs from ALS post mortem explants and in MNs from SOD1G93A mice. Being the retromer involved in trafficking...
Alternative Titles
Full title
Retromer stabilization results in neuroprotection in a model of Amyotrophic Lateral Sclerosis
Authors, Artists and Contributors
Author / Creator
Sirtori, Riccardo
Gornati, Davide
Eleuteri, Simona
Fossaghi, Andrea
Brancaccio, Diego
Manzoni, Leonardo
Ottoboni, Linda
Feo, Luca De
Quattrini, Angelo
Mastrangelo, Eloise
Sorrentino, Luca
Scalone, Emanuele
Comi, Giancarlo
Marinelli, Luciana
Riva, Nilo
Milani, Mario
Seneci, Pierfausto
Martino, Gianvito
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_2a79c2c4685b4d2598d773092d995d7b
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_2a79c2c4685b4d2598d773092d995d7b
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-17524-7
