Formaldehyde reacts with N-terminal proline residues to give bicyclic aminals
Formaldehyde reacts with N-terminal proline residues to give bicyclic aminals
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Formaldehyde (HCHO) is a potent electrophile that is toxic above threshold levels, but which is also produced in the nuclei of eukaryotic cells by demethylases. We report studies with the four canonical human histones revealing that histone H2B reacts with HCHO, including as generated by a histone demethylase, to give a stable product. NMR studies...
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Formaldehyde reacts with N-terminal proline residues to give bicyclic aminals
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TN_cdi_doaj_primary_oai_doaj_org_article_2a8406e75d014635a9536287ad9f6a51
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_2a8406e75d014635a9536287ad9f6a51
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ISSN
2399-3669
E-ISSN
2399-3669
DOI
10.1038/s42004-022-00801-5
