Targeting lonidamine to mitochondria mitigates lung tumorigenesis and brain metastasis
Targeting lonidamine to mitochondria mitigates lung tumorigenesis and brain metastasis
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Lung cancer often has a poor prognosis, with brain metastases a major reason for mortality. We modified lonidamine (LND), an antiglycolytic drug with limited efficacy, to mitochondria-targeted mito-lonidamine (Mito-LND) which is 100-fold more potent. Mito-LND, a tumor-selective inhibitor of oxidative phosphorylation, inhibits mitochondrial bioenerg...
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Targeting lonidamine to mitochondria mitigates lung tumorigenesis and brain metastasis
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TN_cdi_doaj_primary_oai_doaj_org_article_2a91f216e7964b0b95ec04c9938932cc
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_2a91f216e7964b0b95ec04c9938932cc
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-10042-1
