Dilated cardiomyopathy mutation E525K in human beta-cardiac myosin stabilizes the interacting-heads...
Dilated cardiomyopathy mutation E525K in human beta-cardiac myosin stabilizes the interacting-heads motif and super-relaxed state of myosin
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England: eLife Sciences Publications Ltd
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English
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England: eLife Sciences Publications Ltd
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The auto-inhibited, super-relaxed (SRX) state of cardiac myosin is thought to be crucial for regulating contraction, relaxation, and energy conservation in the heart. We used single ATP turnover experiments to demonstrate that a dilated cardiomyopathy (DCM) mutation (E525K) in human beta-cardiac myosin increases the fraction of myosin heads in the...
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Dilated cardiomyopathy mutation E525K in human beta-cardiac myosin stabilizes the interacting-heads motif and super-relaxed state of myosin
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TN_cdi_doaj_primary_oai_doaj_org_article_2a972567fd55436c8074580ba6a5c3a8
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_2a972567fd55436c8074580ba6a5c3a8
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2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.77415
