Mitochondrial CISD1/Cisd accumulation blocks mitophagy and genetic or pharmacological inhibition res...
Mitochondrial CISD1/Cisd accumulation blocks mitophagy and genetic or pharmacological inhibition rescues neurodegenerative phenotypes in Pink1/parkin models
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Publisher
England: BioMed Central Ltd
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Language
English
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England: BioMed Central Ltd
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Mitochondrial dysfunction and toxic protein aggregates have been shown to be key features in the pathogenesis of neurodegenerative diseases, such as Parkinson's disease (PD). Functional analysis of genes linked to PD have revealed that the E3 ligase Parkin and the mitochondrial kinase PINK1 are important factors for mitochondrial quality control. P...
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Mitochondrial CISD1/Cisd accumulation blocks mitophagy and genetic or pharmacological inhibition rescues neurodegenerative phenotypes in Pink1/parkin models
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TN_cdi_doaj_primary_oai_doaj_org_article_2aa9e015c08a421a94ce4e2d5ab28568
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_2aa9e015c08a421a94ce4e2d5ab28568
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ISSN
1750-1326
E-ISSN
1750-1326
DOI
10.1186/s13024-024-00701-3
