KDM6B promotes activation of the oncogenic CDK4/6-pRB-E2F pathway by maintaining enhancer activity i...
KDM6B promotes activation of the oncogenic CDK4/6-pRB-E2F pathway by maintaining enhancer activity in MYCN-amplified neuroblastoma
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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The H3K27me2/me3 histone demethylase KDM6B is essential to neuroblastoma cell survival. However, the mechanism of KDM6B action remains poorly defined. We demonstrate that inhibition of KDM6B activity 1) reduces the chromatin accessibility of E2F target genes and
MYCN, 2)
selectively leads to an increase of H3K27me3 but a decrease of the enhan...
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KDM6B promotes activation of the oncogenic CDK4/6-pRB-E2F pathway by maintaining enhancer activity in MYCN-amplified neuroblastoma
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TN_cdi_doaj_primary_oai_doaj_org_article_2ad9ab2b23fe41648721a58a68144d5b
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_2ad9ab2b23fe41648721a58a68144d5b
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-27502-2
