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CD47 agonist peptides induce programmed cell death in refractory chronic lymphocytic leukemia B cell...

CD47 agonist peptides induce programmed cell death in refractory chronic lymphocytic leukemia B cell...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_2b2543ff56164dc3bf8abd1cd6e551be

CD47 agonist peptides induce programmed cell death in refractory chronic lymphocytic leukemia B cells via PLCγ1 activation: evidence from mice and humans

About this item

Full title

CD47 agonist peptides induce programmed cell death in refractory chronic lymphocytic leukemia B cells via PLCγ1 activation: evidence from mice and humans

Publisher

United States: Public Library of Science

Journal title

PLoS medicine, 2015-03, Vol.12 (3), p.e1001796

Language

English

Formats

Publication information

Publisher

United States: Public Library of Science

More information

Scope and Contents

Contents

Chronic lymphocytic leukemia (CLL), the most common adulthood leukemia, is characterized by the accumulation of abnormal CD5+ B lymphocytes, which results in a progressive failure of the immune system. Despite intense research efforts, drug resistance remains a major cause of treatment failure in CLL, particularly in patients with dysfunctional TP5...

Alternative Titles

Full title

CD47 agonist peptides induce programmed cell death in refractory chronic lymphocytic leukemia B cells via PLCγ1 activation: evidence from mice and humans

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_2b2543ff56164dc3bf8abd1cd6e551be

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_2b2543ff56164dc3bf8abd1cd6e551be

Other Identifiers

ISSN

1549-1676,1549-1277

E-ISSN

1549-1676

DOI

10.1371/journal.pmed.1001796

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