Disparate bone anabolic cues activate bone formation by regulating the rapid lysosomal degradation o...
Disparate bone anabolic cues activate bone formation by regulating the rapid lysosomal degradation of sclerostin protein
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England: eLife Science Publications, Ltd
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Language
English
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England: eLife Science Publications, Ltd
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The downregulation of sclerostin in osteocytes mediates bone formation in response to mechanical cues and parathyroid hormone (PTH). To date, the regulation of sclerostin has been attributed exclusively to the transcriptional downregulation of the
Sost
gene hours after stimulation. Using mouse models and rodent cell lines, we describe the rap...
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Full title
Disparate bone anabolic cues activate bone formation by regulating the rapid lysosomal degradation of sclerostin protein
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TN_cdi_doaj_primary_oai_doaj_org_article_2b300c8844e542adbe2dc058ecb04f02
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_2b300c8844e542adbe2dc058ecb04f02
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.64393
