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Arginase 1 is a key driver of immune suppression in pancreatic cancer

Arginase 1 is a key driver of immune suppression in pancreatic cancer

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_2b78244f89f74a1a8452e4521a5af646

Arginase 1 is a key driver of immune suppression in pancreatic cancer

About this item

Full title

Arginase 1 is a key driver of immune suppression in pancreatic cancer

Publisher

England: eLife Sciences Publications Ltd

Journal title

eLife, 2023-02, Vol.12

Language

English

Formats

Publication information

Publisher

England: eLife Sciences Publications Ltd

More information

Scope and Contents

Contents

An extensive fibroinflammatory stroma rich in macrophages is a hallmark of pancreatic cancer. In this disease, it is well appreciated that macrophages are immunosuppressive and contribute to the poor response to immunotherapy; however, the mechanisms of immune suppression are complex and not fully understood. Immunosuppressive macrophages are class...

Alternative Titles

Full title

Arginase 1 is a key driver of immune suppression in pancreatic cancer

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_doaj_primary_oai_doaj_org_article_2b78244f89f74a1a8452e4521a5af646

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_2b78244f89f74a1a8452e4521a5af646

Other Identifiers

ISSN

2050-084X

E-ISSN

2050-084X

DOI

10.7554/eLife.80721

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