Orphan receptor GPR37L1 contributes to the sexual dimorphism of central cardiovascular control
Orphan receptor GPR37L1 contributes to the sexual dimorphism of central cardiovascular control
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Author / Creator
Coleman, James L. J. , Mouat, Margaret A. , Wu, Jianxin , Jancovski, Nikola , Bassi, Jaspreet K. , Chan, Andrea Y. , Humphreys, David T. , Mrad, Nadine , Yu, Ze-Yan , Ngo, Tony , Iismaa, Siiri , dos Remedios, Cristobal G. , Feneley, Michael P. , Allen, Andrew M. , Graham, Robert M. and Smith, Nicola J.
Publisher
England: BioMed Central Ltd
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English
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England: BioMed Central Ltd
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Contents
Over 100 mammalian G protein-coupled receptors are yet to be matched with endogenous ligands; these so-called orphans are prospective drug targets for the treatment of disease. GPR37L1 is one such orphan, abundant in the brain and detectable as mRNA in the heart and kidney. GPR37L1 ablation was reported to cause hypertension and left ventricular hy...
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Full title
Orphan receptor GPR37L1 contributes to the sexual dimorphism of central cardiovascular control
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TN_cdi_doaj_primary_oai_doaj_org_article_2b7afb49aad2427da3297516bb182039
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_2b7afb49aad2427da3297516bb182039
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ISSN
2042-6410
E-ISSN
2042-6410
DOI
10.1186/s13293-018-0173-y