Cripto is essential to capture mouse epiblast stem cell and human embryonic stem cell pluripotency
Cripto is essential to capture mouse epiblast stem cell and human embryonic stem cell pluripotency
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Author / Creator
Fiorenzano, Alessandro , Pascale, Emilia , D'Aniello, Cristina , Acampora, Dario , Bassalert, Cecilia , Russo, Francesco , Andolfi, Gennaro , Biffoni, Mauro , Francescangeli, Federica , Zeuner, Ann , Angelini, Claudia , Chazaud, Claire , Patriarca, Eduardo J. , Fico, Annalisa and Minchiotti, Gabriella
Publisher
London: Nature Publishing Group UK
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English
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Publisher
London: Nature Publishing Group UK
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Contents
Known molecular determinants of developmental plasticity are mainly transcription factors, while the extrinsic regulation of this process has been largely unexplored. Here we identify Cripto as one of the earliest epiblast markers and a key extracellular determinant of the naive and primed pluripotent states. We demonstrate that Cripto sustains mou...
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Full title
Cripto is essential to capture mouse epiblast stem cell and human embryonic stem cell pluripotency
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TN_cdi_doaj_primary_oai_doaj_org_article_2bb01357f66344a6adf138525180fdf0
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_2bb01357f66344a6adf138525180fdf0
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms12589
