Simulation-Based Assessment of the Impact of Non-Adherence on Endoxifen Target Attainment in Differe...
Simulation-Based Assessment of the Impact of Non-Adherence on Endoxifen Target Attainment in Different Tamoxifen Dosing Strategies
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Switzerland: MDPI AG
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Language
English
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Switzerland: MDPI AG
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Tamoxifen is widely used in breast cancer treatment and minimum steady-state concentrations of its active metabolite endoxifen (CSS,min ENDX) above 5.97 ng/mL have been associated with favourable disease outcome. Yet, about 20% of patients do not reach target CSS,min ENDX applying conventional tamoxifen dosing. Moreover, 4–75% of patients are non-a...
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Simulation-Based Assessment of the Impact of Non-Adherence on Endoxifen Target Attainment in Different Tamoxifen Dosing Strategies
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TN_cdi_doaj_primary_oai_doaj_org_article_2c22f6de0b6c42f6b68afc845c3dd2b6
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_2c22f6de0b6c42f6b68afc845c3dd2b6
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ISSN
1424-8247
E-ISSN
1424-8247
DOI
10.3390/ph14020115
