PLZF targets developmental enhancers for activation during osteogenic differentiation of human mesen...
PLZF targets developmental enhancers for activation during osteogenic differentiation of human mesenchymal stem cells
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England: eLife Sciences Publications Ltd
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English
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England: eLife Sciences Publications Ltd
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The PLZF transcription factor is essential for osteogenic differentiation of hMSCs; however, its regulation and molecular function during this process is not fully understood. Here, we revealed that the ZBTB16 locus encoding PLZF, is repressed by Polycomb (PcG) and H3K27me3 in naive hMSCs. At the pre-osteoblast stage of differentiation, the locus l...
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PLZF targets developmental enhancers for activation during osteogenic differentiation of human mesenchymal stem cells
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TN_cdi_doaj_primary_oai_doaj_org_article_2c7c464f81894c2a99ba1da3eb3405fb
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_2c7c464f81894c2a99ba1da3eb3405fb
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.40364
