Hyodeoxycholic acid ameliorates nonalcoholic fatty liver disease by inhibiting RAN-mediated PPARα nu...
Hyodeoxycholic acid ameliorates nonalcoholic fatty liver disease by inhibiting RAN-mediated PPARα nucleus-cytoplasm shuttling
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Author / Creator
Zhong, Jing , He, Xiaofang , Gao, Xinxin , Liu, Qiaohong , Zhao, Yu , Hong, Ying , Zhu, Weize , Yan, Juan , Li, Yifan , Li, Yan , Zheng, Ningning , Bao, Yiyang , Wang, Hao , Ma, Junli , Huang, Wenjin , Liu, Zekun , Lyu, Yuanzhi , Ke, Xisong , Jia, Wei , Xie, Cen , Hu, Yiyang , Sheng, Lili and Li, Houkai
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Nonalcoholic fatty liver disease (NAFLD) is usually characterized with disrupted bile acid (BA) homeostasis. However, the exact role of certain BA in NAFLD is poorly understood. Here we show levels of serum hyodeoxycholic acid (HDCA) decrease in both NAFLD patients and mice, as well as in liver and intestinal contents of NAFLD mice compared to thei...
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Full title
Hyodeoxycholic acid ameliorates nonalcoholic fatty liver disease by inhibiting RAN-mediated PPARα nucleus-cytoplasm shuttling
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TN_cdi_doaj_primary_oai_doaj_org_article_2cabde00095247bba8fbae026c8d9d01
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_2cabde00095247bba8fbae026c8d9d01
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-41061-8
