Proteasome inhibition targets the KMT2A transcriptional complex in acute lymphoblastic leukemia
Proteasome inhibition targets the KMT2A transcriptional complex in acute lymphoblastic leukemia
About this item
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Author / Creator
Kamens, Jennifer L. , Nance, Stephanie , Koss, Cary , Xu, Beisi , Cotton, Anitria , Lam, Jeannie W. , Garfinkle, Elizabeth A. R. , Nallagatla, Pratima , Smith, Amelia M. R. , Mitchell, Sharnise , Ma, Jing , Currier, Duane , Wright, William C. , Kavdia, Kanisha , Pagala, Vishwajeeth R. , Kim, Wonil , Wallace, LaShanale M. , Cho, Ji-Hoon , Fan, Yiping , Seth, Aman , Twarog, Nathaniel , Choi, John K. , Obeng, Esther A. , Hatley, Mark E. , Metzger, Monika L. , Inaba, Hiroto , Jeha, Sima , Rubnitz, Jeffrey E. , Peng, Junmin , Chen, Taosheng , Shelat, Anang A. , Guy, R. Kiplin and Gruber, Tanja A.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Rearrangments in Histone-lysine-N-methyltransferase 2A (KMT2Ar) are associated with pediatric, adult and therapy-induced acute leukemias. Infants with KMT2Ar acute lymphoblastic leukemia (ALL) have a poor prognosis with an event-free-survival of 38%. Herein we evaluate 1116 FDA approved compounds in primary KMT2Ar infant ALL specimens and identify...
Alternative Titles
Full title
Proteasome inhibition targets the KMT2A transcriptional complex in acute lymphoblastic leukemia
Authors, Artists and Contributors
Author / Creator
Nance, Stephanie
Koss, Cary
Xu, Beisi
Cotton, Anitria
Lam, Jeannie W.
Garfinkle, Elizabeth A. R.
Nallagatla, Pratima
Smith, Amelia M. R.
Mitchell, Sharnise
Ma, Jing
Currier, Duane
Wright, William C.
Kavdia, Kanisha
Pagala, Vishwajeeth R.
Kim, Wonil
Wallace, LaShanale M.
Cho, Ji-Hoon
Fan, Yiping
Seth, Aman
Twarog, Nathaniel
Choi, John K.
Obeng, Esther A.
Hatley, Mark E.
Metzger, Monika L.
Inaba, Hiroto
Jeha, Sima
Rubnitz, Jeffrey E.
Peng, Junmin
Chen, Taosheng
Shelat, Anang A.
Guy, R. Kiplin
Gruber, Tanja A.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_2cd886b587c94bdaa2bd04fdff849913
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_2cd886b587c94bdaa2bd04fdff849913
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-36370-x
