Cyclin-Dependent Kinase 18 Controls Trafficking of Aquaporin-2 and Its Abundance through Ubiquitin L...
Cyclin-Dependent Kinase 18 Controls Trafficking of Aquaporin-2 and Its Abundance through Ubiquitin Ligase STUB1, Which Functions as an AKAP
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Author / Creator
Dema, Alessandro , Faust, Dörte , Lazarow, Katina , Wippich, Marc , Neuenschwander, Martin , Zühlke, Kerstin , Geelhaar, Andrea , Pallien, Tamara , Hallscheidt, Eileen , Eichhorst, Jenny , Wiesner, Burkhard , Černecká, Hana , Popp, Oliver , Mertins, Philipp , Dittmar, Gunnar , von Kries, Jens Peter and Klussmann, Enno
Publisher
Switzerland: MDPI
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Language
English
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Publisher
Switzerland: MDPI
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Contents
Arginine-vasopressin (AVP) facilitates water reabsorption in renal collecting duct principal cells through regulation of the water channel aquaporin-2 (AQP2). The hormone binds to vasopressin V2 receptors (V2R) on the surface of the cells and stimulates cAMP synthesis. The cAMP activates protein kinase A (PKA), which initiates signaling that causes...
Alternative Titles
Full title
Cyclin-Dependent Kinase 18 Controls Trafficking of Aquaporin-2 and Its Abundance through Ubiquitin Ligase STUB1, Which Functions as an AKAP
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Author / Creator
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_2e53df9d47594aa78197c2dae41ffcc8
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_2e53df9d47594aa78197c2dae41ffcc8
Other Identifiers
ISSN
2073-4409
E-ISSN
2073-4409
DOI
10.3390/cells9030673
