Dysregulated splicing factor SF3B1 unveils a dual therapeutic vulnerability to target pancreatic can...
Dysregulated splicing factor SF3B1 unveils a dual therapeutic vulnerability to target pancreatic cancer cells and cancer stem cells with an anti-splicing drug
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Author / Creator
Alors-Perez, Emilia , Blázquez-Encinas, Ricardo , Alcalá, Sonia , Viyuela-García, Cristina , Pedraza-Arevalo, Sergio , Herrero-Aguayo, Vicente , Jiménez-Vacas, Juan M. , Mafficini, Andrea , Sánchez-Frías, Marina E. , Cano, María T. , Abollo-Jiménez, Fernando , Marín-Sanz, Juan A. , Cabezas-Sainz, Pablo , Lawlor, Rita T. , Luchini, Claudio , Sánchez, Laura , Sánchez-Hidalgo, Juan M. , Ventura, Sebastián , Martin-Hijano, Laura , Gahete, Manuel D. , Scarpa, Aldo , Arjona-Sánchez, Álvaro , Ibáñez-Costa, Alejandro , Sainz, Bruno , Luque, Raúl M. and Castaño, Justo P.
Publisher
England: BioMed Central Ltd
Journal title
Language
English
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Publication information
Publisher
England: BioMed Central Ltd
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More information
Scope and Contents
Contents
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer, requiring novel treatments to target both cancer cells and cancer stem cells (CSCs). Altered splicing is emerging as both a novel cancer hallmark and an attractive therapeutic target. The core splicing factor SF3B1 is heavily altered in cancer and can be inhibited by Pladienolide-B,...
Alternative Titles
Full title
Dysregulated splicing factor SF3B1 unveils a dual therapeutic vulnerability to target pancreatic cancer cells and cancer stem cells with an anti-splicing drug
Authors, Artists and Contributors
Author / Creator
Blázquez-Encinas, Ricardo
Alcalá, Sonia
Viyuela-García, Cristina
Pedraza-Arevalo, Sergio
Herrero-Aguayo, Vicente
Jiménez-Vacas, Juan M.
Mafficini, Andrea
Sánchez-Frías, Marina E.
Cano, María T.
Abollo-Jiménez, Fernando
Marín-Sanz, Juan A.
Cabezas-Sainz, Pablo
Lawlor, Rita T.
Luchini, Claudio
Sánchez, Laura
Sánchez-Hidalgo, Juan M.
Ventura, Sebastián
Martin-Hijano, Laura
Gahete, Manuel D.
Scarpa, Aldo
Arjona-Sánchez, Álvaro
Ibáñez-Costa, Alejandro
Sainz, Bruno
Luque, Raúl M.
Castaño, Justo P.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_2e57a0d7fd7f42d6a9f88e1c0cae6aca
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_2e57a0d7fd7f42d6a9f88e1c0cae6aca
Other Identifiers
ISSN
1756-9966,0392-9078
E-ISSN
1756-9966
DOI
10.1186/s13046-021-02153-9
