Contributing factors to the oxidation-induced mutational landscape in human cells
Contributing factors to the oxidation-induced mutational landscape in human cells
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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8-oxoguanine (8-oxoG) is a common oxidative DNA lesion that causes G > T substitutions. Determinants of local and regional differences in 8-oxoG-induced mutability across genomes are currently unknown. Here, we show DNA oxidation induces G > T substitutions and insertion/deletion (INDEL) mutations in human cells and cancers. Potassium bromate (KBrO...
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Contributing factors to the oxidation-induced mutational landscape in human cells
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TN_cdi_doaj_primary_oai_doaj_org_article_2e6e11d04e8d4509a18710060f78dab7
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_2e6e11d04e8d4509a18710060f78dab7
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-024-55497-z
