Accelerated lysine metabolism conveys kidney protection in salt-sensitive hypertension
Accelerated lysine metabolism conveys kidney protection in salt-sensitive hypertension
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Full title
Author / Creator
Rinschen, Markus M. , Palygin, Oleg , El-Meanawy, Ashraf , Domingo-Almenara, Xavier , Palermo, Amelia , Dissanayake, Lashodya V. , Golosova, Daria , Schafroth, Michael A. , Guijas, Carlos , Demir, Fatih , Jaegers, Johannes , Gliozzi, Megan L. , Xue, Jingchuan , Hoehne, Martin , Benzing, Thomas , Kok, Bernard P. , Saez, Enrique , Bleich, Markus , Himmerkus, Nina , Weisz, Ora A. , Cravatt, Benjamin F. , Krüger, Marcus , Benton, H. Paul , Siuzdak, Gary and Staruschenko, Alexander
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Hypertension and kidney disease have been repeatedly associated with genomic variants and alterations of lysine metabolism. Here, we combined stable isotope labeling with untargeted metabolomics to investigate lysine’s metabolic fate in vivo. Dietary
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labeled lysine was tracked to lysine metabolites across various organs. Globally...
Alternative Titles
Full title
Accelerated lysine metabolism conveys kidney protection in salt-sensitive hypertension
Authors, Artists and Contributors
Author / Creator
Palygin, Oleg
El-Meanawy, Ashraf
Domingo-Almenara, Xavier
Palermo, Amelia
Dissanayake, Lashodya V.
Golosova, Daria
Schafroth, Michael A.
Guijas, Carlos
Demir, Fatih
Jaegers, Johannes
Gliozzi, Megan L.
Xue, Jingchuan
Hoehne, Martin
Benzing, Thomas
Kok, Bernard P.
Saez, Enrique
Bleich, Markus
Himmerkus, Nina
Weisz, Ora A.
Cravatt, Benjamin F.
Krüger, Marcus
Benton, H. Paul
Siuzdak, Gary
Staruschenko, Alexander
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_2e9849a398d242b7a32232ec6d46f7d8
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_2e9849a398d242b7a32232ec6d46f7d8
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-022-31670-0
