De novo generation of SARS-CoV-2 antibody CDRH3 with a pre-trained generative large language model
De novo generation of SARS-CoV-2 antibody CDRH3 with a pre-trained generative large language model
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Author / Creator
He, Haohuai , He, Bing , Guan, Lei , Zhao, Yu , Jiang, Feng , Chen, Guanxing , Zhu, Qingge , Chen, Calvin Yu-Chian , Li, Ting and Yao, Jianhua
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Artificial Intelligence (AI) techniques have made great advances in assisting antibody design. However, antibody design still heavily relies on isolating antigen-specific antibodies from serum, which is a resource-intensive and time-consuming process. To address this issue, we propose a Pre-trained Antibody generative large Language Model (PALM-H3)...
Alternative Titles
Full title
De novo generation of SARS-CoV-2 antibody CDRH3 with a pre-trained generative large language model
Authors, Artists and Contributors
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_2edee7142e52406ba5b3dcb054681403
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_2edee7142e52406ba5b3dcb054681403
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-024-50903-y
