Phf8 histone demethylase deficiency causes cognitive impairments through the mTOR pathway
Phf8 histone demethylase deficiency causes cognitive impairments through the mTOR pathway
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Author / Creator
Chen, Xuemei , Wang, Shuai , Zhou, Ying , Han, Yanfei , Li, Shengtian , Xu, Qing , Xu, Longyong , Zhu, Ziqi , Deng, Youming , Yu, Lu , Song, Lulu , Chen, Adele Pin , Song, Juan , Takahashi, Eiki , He, Guang , He, Lin , Li, Weidong and Chen, Charlie Degui
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Epigenomic abnormalities caused by genetic mutation in epigenetic regulators can result in neurodevelopmental disorders, deficiency in neural plasticity and mental retardation. As a histone demethylase, plant homeodomain finger protein 8 (
Phf8
) is a candidate gene for syndromal and non-specific forms of X-chromosome-linked intellectual disa...
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Full title
Phf8 histone demethylase deficiency causes cognitive impairments through the mTOR pathway
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TN_cdi_doaj_primary_oai_doaj_org_article_2ef75b4f01b048c09a3f547f5a48ff9a
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_2ef75b4f01b048c09a3f547f5a48ff9a
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-017-02531-y
