PI3K activation allows immune evasion by promoting an inhibitory myeloid tumor microenvironment
PI3K activation allows immune evasion by promoting an inhibitory myeloid tumor microenvironment
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Author / Creator
Collins, Natalie B , Al Abosy, Rose , Miller, Brian C , Bi, Kevin , Zhao, Qihong , Quigley, Michael , Ishizuka, Jeffrey J , Yates, Kathleen B , Pope, Hans W , Manguso, Robert T , Shrestha, Yashaswi , Wadsworth, Marc , Hughes, Travis , Shalek, Alex K , Boehm, Jesse S , Hahn, William C , Doench, John G and Haining, W Nicholas
Publisher
England: BMJ Publishing Group Ltd
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Language
English
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Publisher
England: BMJ Publishing Group Ltd
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BackgroundOncogenes act in a cell-intrinsic way to promote tumorigenesis. Whether oncogenes also have a cell-extrinsic effect on suppressing the immune response to cancer is less well understood.MethodsWe use an in vivo expression screen of known cancer-associated somatic mutations in mouse syngeneic tumor models treated with checkpoint blockade to...
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Full title
PI3K activation allows immune evasion by promoting an inhibitory myeloid tumor microenvironment
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TN_cdi_doaj_primary_oai_doaj_org_article_2f18639e65804873a00ab93aef07c6bc
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_2f18639e65804873a00ab93aef07c6bc
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ISSN
2051-1426
E-ISSN
2051-1426
DOI
10.1136/jitc-2021-003402
