Cancer-associated mutations in DICER1 RNase IIIa and IIIb domains exert similar effects on miRNA bio...
Cancer-associated mutations in DICER1 RNase IIIa and IIIb domains exert similar effects on miRNA biogenesis
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Somatic mutations in the RNase IIIb domain of DICER1 arise in cancer and disrupt the cleavage of 5' pre-miRNA arms. Here, we characterize an unstudied, recurrent, mutation (S1344L) in the DICER1 RNase IIIa domain in tumors from The Cancer Genome Atlas (TCGA) project and MSK-IMPACT profiling. RNase IIIa/b hotspots are absent from most cancers, but a...
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Cancer-associated mutations in DICER1 RNase IIIa and IIIb domains exert similar effects on miRNA biogenesis
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TN_cdi_doaj_primary_oai_doaj_org_article_2f755b2a10804cc9b94ebb7187c03ce0
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_2f755b2a10804cc9b94ebb7187c03ce0
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-11610-1
