RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination
RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination
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England: BioMed Central Ltd
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English
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England: BioMed Central Ltd
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TRIM25 is a novel RNA-binding protein and a member of the Tripartite Motif (TRIM) family of E3 ubiquitin ligases, which plays a pivotal role in the innate immune response. However, there is scarce knowledge about its RNA-related roles in cell biology. Furthermore, its RNA-binding domain has not been characterized.
Here, we reveal that the RNA-bi...
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RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination
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TN_cdi_doaj_primary_oai_doaj_org_article_2f8e9d8eaf534683ae8abdef33ed476b
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_2f8e9d8eaf534683ae8abdef33ed476b
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ISSN
1741-7007
E-ISSN
1741-7007
DOI
10.1186/s12915-017-0444-9
