scRNA-seq in medulloblastoma shows cellular heterogeneity and lineage expansion support resistance t...
scRNA-seq in medulloblastoma shows cellular heterogeneity and lineage expansion support resistance to SHH inhibitor therapy
About this item
Full title
Author / Creator
Ocasio, Jennifer Karin , Babcock, Benjamin , Malawsky, Daniel , Weir, Seth J. , Loo, Lipin , Simon, Jeremy M. , Zylka, Mark J. , Hwang, Duhyeong , Dismuke, Taylor , Sokolsky, Marina , Rosen, Elias P. , Vibhakar, Rajeev , Zhang, Jiao , Saulnier, Olivier , Vladoiu, Maria , El-Hamamy, Ibrahim , Stein, Lincoln D. , Taylor, Michael D. , Smith, Kyle S. , Northcott, Paul A. , Colaneri, Alejandro , Wilhelmsen, Kirk and Gershon, Timothy R.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Targeting oncogenic pathways holds promise for brain tumor treatment, but inhibition of Sonic Hedgehog (SHH) signaling has failed in SHH-driven medulloblastoma. Cellular diversity within tumors and reduced lineage commitment can undermine targeted therapy by increasing the probability of treatment-resistant populations. Using single-cell RNA-seq an...
Alternative Titles
Full title
scRNA-seq in medulloblastoma shows cellular heterogeneity and lineage expansion support resistance to SHH inhibitor therapy
Authors, Artists and Contributors
Author / Creator
Babcock, Benjamin
Malawsky, Daniel
Weir, Seth J.
Loo, Lipin
Simon, Jeremy M.
Zylka, Mark J.
Hwang, Duhyeong
Dismuke, Taylor
Sokolsky, Marina
Rosen, Elias P.
Vibhakar, Rajeev
Zhang, Jiao
Saulnier, Olivier
Vladoiu, Maria
El-Hamamy, Ibrahim
Stein, Lincoln D.
Taylor, Michael D.
Smith, Kyle S.
Northcott, Paul A.
Colaneri, Alejandro
Wilhelmsen, Kirk
Gershon, Timothy R.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_2fac3f5447844cbea3e21cfcf9b5423c
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_2fac3f5447844cbea3e21cfcf9b5423c
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-019-13657-6
