Overcoming myelosuppression due to synthetic lethal toxicity for FLT3-targeted acute myeloid leukemi...
Overcoming myelosuppression due to synthetic lethal toxicity for FLT3-targeted acute myeloid leukemia therapy
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Publisher
England: eLife Sciences Publications Ltd
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Language
English
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England: eLife Sciences Publications Ltd
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Contents
Activating mutations in FLT3 confer poor prognosis for individuals with acute myeloid leukemia (AML). Clinically active investigational FLT3 inhibitors can achieve complete remissions but their utility has been hampered by acquired resistance and myelosuppression attributed to a 'synthetic lethal toxicity' arising from simultaneous inhibition of FL...
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Full title
Overcoming myelosuppression due to synthetic lethal toxicity for FLT3-targeted acute myeloid leukemia therapy
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TN_cdi_doaj_primary_oai_doaj_org_article_2fc4b7634483440a90814b4285cadf5e
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_2fc4b7634483440a90814b4285cadf5e
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ISSN
2050-084X
E-ISSN
2050-084X
DOI
10.7554/eLife.03445
