289 PGV-001: a phase 1 trial of a personalized neoantigen peptide vaccine for the treatment of malig...
289 PGV-001: a phase 1 trial of a personalized neoantigen peptide vaccine for the treatment of malignancies in the adjuvant setting
About this item
Full title
Author / Creator
Marron, Thomas , Kodysh, Julia , Rubinsteyn, Alex , Finnigan, John , Blazquez, Ana , Saxena, Mansi , Meseck, Marcia , O’Donnell, Timothy , Delbeau, Daniela , Galsky, Matthew , Doroshow, Deborah , Miles, Brett , Misiukiewicz, Krysztof , Irie, Hanna , Tiersten, Amy , Parekh, Samir , Posner, Marshall , Wolf, Andrea , Mandeli, John , Hammerbacher, Jeffrey , Donovan, Michael , Brody, Rachel , Gnjatic, Sacha , Schadt, Eric , Friedlander, Philip and Bhardwaj, Nina
Publisher
London: BMJ Publishing Group LTD
Journal title
Language
English
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Publication information
Publisher
London: BMJ Publishing Group LTD
Subjects
More information
Scope and Contents
Contents
BackgroundThe efficacy of T cell directed immunotherapies relies on adequate priming of T cells to tumor-specific neoantigens, which some studies have augmented with synthetic neoantigen vaccines. This is the first report of a personalized genomic vaccine (PGV-001) in multiple histologies in the adjuvant setting.MethodsTumor and germline RNA and DN...
Alternative Titles
Full title
289 PGV-001: a phase 1 trial of a personalized neoantigen peptide vaccine for the treatment of malignancies in the adjuvant setting
Authors, Artists and Contributors
Author / Creator
Kodysh, Julia
Rubinsteyn, Alex
Finnigan, John
Blazquez, Ana
Saxena, Mansi
Meseck, Marcia
O’Donnell, Timothy
Delbeau, Daniela
Galsky, Matthew
Doroshow, Deborah
Miles, Brett
Misiukiewicz, Krysztof
Irie, Hanna
Tiersten, Amy
Parekh, Samir
Posner, Marshall
Wolf, Andrea
Mandeli, John
Hammerbacher, Jeffrey
Donovan, Michael
Brody, Rachel
Gnjatic, Sacha
Schadt, Eric
Friedlander, Philip
Bhardwaj, Nina
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_2fdb09ee544e42f79751e40542a845ff
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_2fdb09ee544e42f79751e40542a845ff
Other Identifiers
E-ISSN
2051-1426
DOI
10.1136/jitc-2020-SITC2020.0289
