Targeting the IRE1α/XBP1s pathway suppresses CARM1-expressing ovarian cancer
Targeting the IRE1α/XBP1s pathway suppresses CARM1-expressing ovarian cancer
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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CARM1 is often overexpressed in human cancers including in ovarian cancer. However, therapeutic approaches based on CARM1 expression remain to be an unmet need. Cancer cells exploit adaptive responses such as the endoplasmic reticulum (ER) stress response for their survival through activating pathways such as the IRE1α/XBP1s pathway. Here, we repor...
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Targeting the IRE1α/XBP1s pathway suppresses CARM1-expressing ovarian cancer
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TN_cdi_doaj_primary_oai_doaj_org_article_30c7f569e8f14f29b50078b914b06fde
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_30c7f569e8f14f29b50078b914b06fde
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-021-25684-3
