Structure of lasso peptide epimerase MslH reveals metal-dependent acid/base catalytic mechanism
Structure of lasso peptide epimerase MslH reveals metal-dependent acid/base catalytic mechanism
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
The lasso peptide MS-271 is a ribosomally synthesized and post-translationally modified peptide (RiPP) consisting of 21 amino acids with D-tryptophan at the
C
-terminus, and is derived from the precursor peptide MslA. MslH, encoded in the MS-271 biosynthetic gene cluster (
msl
), catalyzes the epimerization at the Cα center of the MslA<...
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Full title
Structure of lasso peptide epimerase MslH reveals metal-dependent acid/base catalytic mechanism
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TN_cdi_doaj_primary_oai_doaj_org_article_30d4da2d31ea4565ae031fba06ccc808
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_30d4da2d31ea4565ae031fba06ccc808
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-023-40232-x
