Population genetics of PDE4B (phosphodiesterase‐4B) in neglected Native Americans: Implications for...
Population genetics of PDE4B (phosphodiesterase‐4B) in neglected Native Americans: Implications for cancer pharmacogenetics
About this item
Full title
Author / Creator
Moreira, Rennan Garcias , Saraiva‐Duarte, Julia Maria , Pereira, Alexandre Costa , Sosa‐Macias, Martha , Galaviz‐Hernandez, Carlos , Santolalla, Meddly Lesley , Magalhães, Wagner C. S. , Zolini, Camila , Leal, Thiago Peixoto , Balázs, Zsolt , Llerena, Adrián , Gilman, Robert H. , Mill, José Geraldo , Borda, Victor , Guio, Heinner , O’Connor, Timothy D. , Tarazona‐Santos, Eduardo and Rodrigues‐Soares, Fernanda
Publisher
United States: John Wiley & Sons, Inc
Journal title
Language
English
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Publication information
Publisher
United States: John Wiley & Sons, Inc
Subjects
More information
Scope and Contents
Contents
PDE4B (phosphodiesterase‐4B) has an important role in cancer and in pharmacology of some disorders, such as inflammatory diseases. Remarkably in Native Americans, PDE4B variants are associated with acute lymphoblastic leukemia (ALL) relapse, as this gene modulates sensitivity of glucocorticoids used in ALL chemotherapy. PDE4B allele rs6683977.G, as...
Alternative Titles
Full title
Population genetics of PDE4B (phosphodiesterase‐4B) in neglected Native Americans: Implications for cancer pharmacogenetics
Authors, Artists and Contributors
Author / Creator
Saraiva‐Duarte, Julia Maria
Pereira, Alexandre Costa
Sosa‐Macias, Martha
Galaviz‐Hernandez, Carlos
Santolalla, Meddly Lesley
Magalhães, Wagner C. S.
Zolini, Camila
Leal, Thiago Peixoto
Balázs, Zsolt
Llerena, Adrián
Gilman, Robert H.
Mill, José Geraldo
Borda, Victor
Guio, Heinner
O’Connor, Timothy D.
Tarazona‐Santos, Eduardo
Rodrigues‐Soares, Fernanda
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_30e45fe2f5a74ed1a2c2287f6df6d9e9
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_30e45fe2f5a74ed1a2c2287f6df6d9e9
Other Identifiers
ISSN
1752-8054
E-ISSN
1752-8062
DOI
10.1111/cts.13266
