Inhibition of PI3K suppresses propagation of drug-tolerant cancer cell subpopulations enriched by 5-...
Inhibition of PI3K suppresses propagation of drug-tolerant cancer cell subpopulations enriched by 5-fluorouracil
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Drug-tolerant cancer cell subpopulations are responsible for relapse after chemotherapy. By continuously exposing the gastric cancer cell line MKN45 to 5-FU for >100 passages, we established a 5-fluorouracil (5-FU)-tolerant line, MKN45/5FU. Orthotopic xenografts of MKN45/5FU cells in the stomach of nude mice revealed that these cells had a high pot...
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Inhibition of PI3K suppresses propagation of drug-tolerant cancer cell subpopulations enriched by 5-fluorouracil
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TN_cdi_doaj_primary_oai_doaj_org_article_30e51fd4b7c44c4ca3d2cc55585da6d6
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_30e51fd4b7c44c4ca3d2cc55585da6d6
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-017-02548-9
