Altered mGluR5-Homer scaffolds and corticostriatal connectivity in a Shank3 complete knockout model...
Altered mGluR5-Homer scaffolds and corticostriatal connectivity in a Shank3 complete knockout model of autism
About this item
Full title
Author / Creator
Wang, Xiaoming , Bey, Alexandra L. , Katz, Brittany M. , Badea, Alexandra , Kim, Namsoo , David, Lisa K. , Duffney, Lara J. , Kumar, Sunil , Mague, Stephen D. , Hulbert, Samuel W. , Dutta, Nisha , Hayrapetyan, Volodya , Yu, Chunxiu , Gaidis, Erin , Zhao, Shengli , Ding, Jin-Dong , Xu, Qiong , Chung, Leeyup , Rodriguiz, Ramona M. , Wang, Fan , Weinberg, Richard J. , Wetsel, William C. , Dzirasa, Kafui , Yin, Henry and Jiang, Yong-hui
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Human neuroimaging studies suggest that aberrant neural connectivity underlies behavioural deficits in autism spectrum disorders (ASDs), but the molecular and neural circuit mechanisms underlying ASDs remain elusive. Here, we describe a complete knockout mouse model of the autism-associated
Shank3
gene, with a deletion of exons 4–22 (Δe4–22)....
Alternative Titles
Full title
Altered mGluR5-Homer scaffolds and corticostriatal connectivity in a Shank3 complete knockout model of autism
Authors, Artists and Contributors
Author / Creator
Bey, Alexandra L.
Katz, Brittany M.
Badea, Alexandra
Kim, Namsoo
David, Lisa K.
Duffney, Lara J.
Kumar, Sunil
Mague, Stephen D.
Hulbert, Samuel W.
Dutta, Nisha
Hayrapetyan, Volodya
Yu, Chunxiu
Gaidis, Erin
Zhao, Shengli
Ding, Jin-Dong
Xu, Qiong
Chung, Leeyup
Rodriguiz, Ramona M.
Wang, Fan
Weinberg, Richard J.
Wetsel, William C.
Dzirasa, Kafui
Yin, Henry
Jiang, Yong-hui
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_31226ec3e0a84099b658a1cc0d12be11
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_31226ec3e0a84099b658a1cc0d12be11
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms11459
