Optimized spirooxindole-pyrazole hybrids targeting the p53-MDM2 interplay induce apoptosis and syner...
Optimized spirooxindole-pyrazole hybrids targeting the p53-MDM2 interplay induce apoptosis and synergize with doxorubicin in A549 cells
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Recently, cancer research protocols have introduced clinical-stage spirooxindole-based MDM2 inhibitors. However, several studies reported tumor resistance to the treatment. This directed efforts to invest in designing various combinatorial libraries of spirooxindoles. Herein, we introduce new series of spirooxindoles via hybridization of the chemic...
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Optimized spirooxindole-pyrazole hybrids targeting the p53-MDM2 interplay induce apoptosis and synergize with doxorubicin in A549 cells
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TN_cdi_doaj_primary_oai_doaj_org_article_3163e75f3ed94e9b89596f628803db7b
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_3163e75f3ed94e9b89596f628803db7b
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2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-023-31209-3
