DNA methylation as a mediator of HLA-DRB115:01 and a protective variant in multiple sclerosis
DNA methylation as a mediator of HLA-DRB115:01 and a protective variant in multiple sclerosis
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Author / Creator
Kular, Lara , Liu, Yun , Ruhrmann, Sabrina , Zheleznyakova, Galina , Marabita, Francesco , Gomez-Cabrero, David , James, Tojo , Ewing, Ewoud , Lindén, Magdalena , Górnikiewicz, Bartosz , Aeinehband, Shahin , Stridh, Pernilla , Link, Jenny , Andlauer, Till F. M. , Gasperi, Christiane , Wiendl, Heinz , Zipp, Frauke , Gold, Ralf , Tackenberg, Björn , Weber, Frank , Hemmer, Bernhard , Strauch, Konstantin , Heilmann-Heimbach, Stefanie , Rawal, Rajesh , Schminke, Ulf , Schmidt, Carsten O. , Kacprowski, Tim , Franke, Andre , Laudes, Matthias , Dilthey, Alexander T. , Celius, Elisabeth G. , Søndergaard, Helle B. , Tegnér, Jesper , Harbo, Hanne F. , Oturai, Annette B. , Olafsson, Sigurgeir , Eggertsson, Hannes P. , Halldorsson, Bjarni V. , Hjaltason, Haukur , Olafsson, Elias , Jonsdottir, Ingileif , Stefansson, Kari , Olsson, Tomas , Piehl, Fredrik , Ekström, Tomas J. , Kockum, Ingrid , Feinberg, Andrew P. and Jagodic, Maja
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
The human leukocyte antigen (HLA) haplotype
DRB1*15
:
01
is the major risk factor for multiple sclerosis (MS). Here, we find that
DRB1*15
:
01
is hypomethylated and predominantly expressed in monocytes among carriers of
DRB1*15
:
01
. A differentially methylated region (DMR) encompassing
HLA-DRB1
exon 2 is...
Alternative Titles
Full title
DNA methylation as a mediator of HLA-DRB115:01 and a protective variant in multiple sclerosis
Authors, Artists and Contributors
Author / Creator
Liu, Yun
Ruhrmann, Sabrina
Zheleznyakova, Galina
Marabita, Francesco
Gomez-Cabrero, David
James, Tojo
Ewing, Ewoud
Lindén, Magdalena
Górnikiewicz, Bartosz
Aeinehband, Shahin
Stridh, Pernilla
Link, Jenny
Andlauer, Till F. M.
Gasperi, Christiane
Wiendl, Heinz
Zipp, Frauke
Gold, Ralf
Tackenberg, Björn
Weber, Frank
Hemmer, Bernhard
Strauch, Konstantin
Heilmann-Heimbach, Stefanie
Rawal, Rajesh
Schminke, Ulf
Schmidt, Carsten O.
Kacprowski, Tim
Franke, Andre
Laudes, Matthias
Dilthey, Alexander T.
Celius, Elisabeth G.
Søndergaard, Helle B.
Tegnér, Jesper
Harbo, Hanne F.
Oturai, Annette B.
Olafsson, Sigurgeir
Eggertsson, Hannes P.
Halldorsson, Bjarni V.
Hjaltason, Haukur
Olafsson, Elias
Jonsdottir, Ingileif
Stefansson, Kari
Olsson, Tomas
Piehl, Fredrik
Ekström, Tomas J.
Kockum, Ingrid
Feinberg, Andrew P.
Jagodic, Maja
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_31861db392bf46669b4a789c9a333f74
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_31861db392bf46669b4a789c9a333f74
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-018-04732-5
