In vivo armed macrophages curb liver metastasis through tumor-reactive T-cell rejuvenation
In vivo armed macrophages curb liver metastasis through tumor-reactive T-cell rejuvenation
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Author / Creator
Notaro, Marco , Borghetti, Maristella , Bresesti, Chiara , Giacca, Giovanna , Kerzel, Thomas , Mercado, Carl Mirko , Beretta, Stefano , Monti, Marco , Merelli, Ivan , Iaia, Silvia , Genua, Marco , Annoni, Andrea , Canu, Tamara , Cristofori, Patrizia , Degl’Innocenti, Sara , Sanvito, Francesca , Rancoita, Paola Maria Vittoria , Ostuni, Renato , Gregori, Silvia , Naldini, Luigi and Squadrito, Mario Leonardo
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Despite recent progress in cancer treatment, liver metastases persist as an unmet clinical need. Here, we show that arming liver and tumor-associated macrophages in vivo to co-express tumor antigens (TAs), IFNα, and IL-12 unleashes robust anti-tumor immune responses, leading to the regression of liver metastases. Mechanistically, in vivo armed macr...
Alternative Titles
Full title
In vivo armed macrophages curb liver metastasis through tumor-reactive T-cell rejuvenation
Authors, Artists and Contributors
Author / Creator
Borghetti, Maristella
Bresesti, Chiara
Giacca, Giovanna
Kerzel, Thomas
Mercado, Carl Mirko
Beretta, Stefano
Monti, Marco
Merelli, Ivan
Iaia, Silvia
Genua, Marco
Annoni, Andrea
Canu, Tamara
Cristofori, Patrizia
Degl’Innocenti, Sara
Sanvito, Francesca
Rancoita, Paola Maria Vittoria
Ostuni, Renato
Gregori, Silvia
Naldini, Luigi
Squadrito, Mario Leonardo
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Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_3192823ab60d481bb6949b7b59cfc444
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_3192823ab60d481bb6949b7b59cfc444
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-025-58369-2
