HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer’s diseas...
HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer’s disease
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Author / Creator
Pao, Ping-Chieh , Patnaik, Debasis , Watson, L. Ashley , Gao, Fan , Pan, Ling , Wang, Jun , Adaikkan, Chinnakkaruppan , Penney, Jay , Cam, Hugh P. , Huang, Wen-Chin , Pantano, Lorena , Lee, Audrey , Nott, Alexi , Phan, Trongha X. , Gjoneska, Elizabeta , Elmsaouri, Sara , Haggarty, Stephen J. and Tsai, Li-Huei
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
DNA damage contributes to brain aging and neurodegenerative diseases. However, the factors stimulating DNA repair to stave off functional decline remain obscure. We show that HDAC1 modulates OGG1-initated 8-oxoguanine (8-oxoG) repair in the brain. HDAC1-deficient mice display age-associated DNA damage accumulation and cognitive impairment. HDAC1 st...
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Full title
HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer’s disease
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_31affdab15104a389accac5fde35981f
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_31affdab15104a389accac5fde35981f
Other Identifiers
ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-020-16361-y
