Investigation into the Use of Encorafenib to Develop Potential PROTACs Directed against BRAFV600E Pr...
Investigation into the Use of Encorafenib to Develop Potential PROTACs Directed against BRAFV600E Protein
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Author / Creator
Marini, Elisabetta , Marino, Marco , Gionfriddo, Giulia , Maione, Federica , Pandini, Marta , Oddo, Daniele , Giorgis, Marta , Rolando, Barbara , Blua, Federica , Gastaldi, Simone , Marchiò, Serena , Kovachka, Sandra , Spyrakis, Francesca , Gianquinto, Eleonora , Di Nicolantonio, Federica and Bertinaria, Massimo
Publisher
Basel: MDPI AG
Journal title
Language
English
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Publication information
Publisher
Basel: MDPI AG
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Scope and Contents
Contents
BRAF is a serine/threonine kinase frequently mutated in human cancers. BRAFV600E mutated protein is targeted through the use of kinase inhibitors which are approved for the treatment of melanoma; however, their long-term efficacy is hampered by resistance mechanisms. The PROTAC-induced degradation of BRAFV600E has been proposed as an alternative st...
Alternative Titles
Full title
Investigation into the Use of Encorafenib to Develop Potential PROTACs Directed against BRAFV600E Protein
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Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_321ff11884e9491784732a391526bf64
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_321ff11884e9491784732a391526bf64
Other Identifiers
ISSN
1420-3049
E-ISSN
1420-3049
DOI
10.3390/molecules27238513
