Calcium and Redox Liaison: A Key Role of Selenoprotein N in Skeletal Muscle
Calcium and Redox Liaison: A Key Role of Selenoprotein N in Skeletal Muscle
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Basel: MDPI AG
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Language
English
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Basel: MDPI AG
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Contents
Selenoprotein N (SEPN1) is a type II glycoprotein of the endoplasmic reticulum (ER) that senses calcium levels to tune the activity of the sarcoplasmic reticulum calcium pump (SERCA pump) through a redox-mediated mechanism, modulating ER calcium homeostasis. In SEPN1-depleted muscles, altered ER calcium homeostasis triggers ER stress, which induces...
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Full title
Calcium and Redox Liaison: A Key Role of Selenoprotein N in Skeletal Muscle
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TN_cdi_doaj_primary_oai_doaj_org_article_3220fb6433cb4d78bc03dd50074e0305
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_3220fb6433cb4d78bc03dd50074e0305
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ISSN
2073-4409
E-ISSN
2073-4409
DOI
10.3390/cells10051116
