A human model to deconvolve genotype-phenotype causations in lung squamous cell carcinoma
A human model to deconvolve genotype-phenotype causations in lung squamous cell carcinoma
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Tractable, patient-relevant models are needed to investigate cancer progression and heterogeneity. Here, we report an alternative in vitro model of lung squamous cell carcinoma (LUSC) using primary human bronchial epithelial cells (hBECs) from three healthy donors. The co-operation of ubiquitous alterations (
TP53
and
CDKN2A
loss) and c...
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Full title
A human model to deconvolve genotype-phenotype causations in lung squamous cell carcinoma
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TN_cdi_doaj_primary_oai_doaj_org_article_324750c9b05d4fda8a7667c610e87fe9
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_324750c9b05d4fda8a7667c610e87fe9
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/s41467-025-58343-y
