Intestinal stem cell aging signature reveals a reprogramming strategy to enhance regenerative potent...
Intestinal stem cell aging signature reveals a reprogramming strategy to enhance regenerative potential
About this item
Full title
Author / Creator
Nefzger, Christian M. , Jardé, Thierry , Srivastava, Akanksha , Schroeder, Jan , Rossello, Fernando J. , Horvay, Katja , Prasko, Mirsada , Paynter, Jacob M. , Chen, Joseph , Weng, Chen-Fang , Sun, Yu B. Y. , Liu, Xiaodong , Chan, Eva , Deshpande, Nikita , Chen, Xiaoli , Li, Y. Jinhua , Pflueger, Jahnvi , Engel, Rebekah M. , Knaupp, Anja S. , Tsyganov, Kirill , Nilsson, Susan K. , Lister, Ryan , Rackham, Owen J. L. , Abud, Helen E. and Polo, Jose M.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
The impact of aging on intestinal stem cells (ISCs) has not been fully elucidated. In this study, we identified widespread epigenetic and transcriptional alterations in old ISCs. Using a reprogramming algorithm, we identified a set of key transcription factors (
Egr1, Irf1, FosB
) that drives molecular and functional differences between old a...
Alternative Titles
Full title
Intestinal stem cell aging signature reveals a reprogramming strategy to enhance regenerative potential
Authors, Artists and Contributors
Author / Creator
Jardé, Thierry
Srivastava, Akanksha
Schroeder, Jan
Rossello, Fernando J.
Horvay, Katja
Prasko, Mirsada
Paynter, Jacob M.
Chen, Joseph
Weng, Chen-Fang
Sun, Yu B. Y.
Liu, Xiaodong
Chan, Eva
Deshpande, Nikita
Chen, Xiaoli
Li, Y. Jinhua
Pflueger, Jahnvi
Engel, Rebekah M.
Knaupp, Anja S.
Tsyganov, Kirill
Nilsson, Susan K.
Lister, Ryan
Rackham, Owen J. L.
Abud, Helen E.
Polo, Jose M.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_doaj_primary_oai_doaj_org_article_325c54d2ea294a94afa02fa43f4f567c
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_325c54d2ea294a94afa02fa43f4f567c
Other Identifiers
ISSN
2057-3995
E-ISSN
2057-3995
DOI
10.1038/s41536-022-00226-7
