New structure-activity relationships of chalcone inhibitors of breast cancer resistance protein: pol...
New structure-activity relationships of chalcone inhibitors of breast cancer resistance protein: polyspecificity toward inhibition and critical substitutions against cytotoxicity
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New Zealand: Dove Medical Press Limited
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Language
English
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Publisher
New Zealand: Dove Medical Press Limited
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Contents
Adenosine triphosphate-binding cassette subfamily G member 2 (ABCG2) plays a major role in cancer cell multidrug resistance, which contributes to low efficacy of chemotherapy. Chalcones were recently found to be potent and specific inhibitors, but unfortunately display a significant cytotoxicity. A cellular screening against ABCG2-mediated mitoxant...
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Full title
New structure-activity relationships of chalcone inhibitors of breast cancer resistance protein: polyspecificity toward inhibition and critical substitutions against cytotoxicity
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TN_cdi_doaj_primary_oai_doaj_org_article_3269e9c2beee4a16a832611a24d52894
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_3269e9c2beee4a16a832611a24d52894
Other Identifiers
ISSN
1177-8881
E-ISSN
1177-8881
DOI
10.2147/DDDT.S46983
