Effect of Conformational Diversity on the Bioactivity of µ-Conotoxin PIIIA Disulfide Isomers
Effect of Conformational Diversity on the Bioactivity of µ-Conotoxin PIIIA Disulfide Isomers
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Switzerland: MDPI AG
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Language
English
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Switzerland: MDPI AG
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Cyclic µ-conotoxin PIIIA, a potent blocker of skeletal muscle voltage-gated sodium channel Na
1.4, is a 22mer peptide stabilized by three disulfide bonds. Combining electrophysiological measurements with molecular docking and dynamic simulations based on NMR solution structures, we investigated the 15 possible 3-disulfide-bonded isomers of µ-PII...
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Effect of Conformational Diversity on the Bioactivity of µ-Conotoxin PIIIA Disulfide Isomers
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TN_cdi_doaj_primary_oai_doaj_org_article_32742123ecf1403585f3326f2a9638c7
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_32742123ecf1403585f3326f2a9638c7
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ISSN
1660-3397
E-ISSN
1660-3397
DOI
10.3390/md17070390
