Increased hepatoprotective effects of the novel farnesoid X receptor agonist INT-787 versus obeticho...
Increased hepatoprotective effects of the novel farnesoid X receptor agonist INT-787 versus obeticholic acid in a mouse model of nonalcoholic steatohepatitis
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United States: Public Library of Science
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English
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United States: Public Library of Science
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The nuclear farnesoid X receptor (FXR), a master regulator of bile acid and metabolic homeostasis, is a key target for treatment of nonalcoholic steatohepatitis (NASH). This study compared efficacy of FXR agonists obeticholic acid (OCA) and INT-787 by liver histopathology, plasma biomarkers of liver damage, and hepatic gene expression profiles in t...
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Increased hepatoprotective effects of the novel farnesoid X receptor agonist INT-787 versus obeticholic acid in a mouse model of nonalcoholic steatohepatitis
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TN_cdi_doaj_primary_oai_doaj_org_article_32914ff5801543ee9abbd0125ee55712
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_doaj_primary_oai_doaj_org_article_32914ff5801543ee9abbd0125ee55712
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ISSN
1932-6203
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0300809
